ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity
نویسندگان
چکیده
منابع مشابه
Anti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2
Vascular endothelial growth factor (VEGF)-A blockade has been validated clinically as a treatment for human cancers. Angiopoietin-2 (Ang-2) is a key regulator of blood vessel remodeling and maturation. In tumors, Ang-2 is up-regulated and an unfavorable prognostic factor. Recent data demonstrated that Ang-2 inhibition mediates anti-tumoral effects. We generated a tetravalent bispecific antibody...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2010
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-010-0431-6